Protein Details: Potassium voltage-gated channel subfamily C member 1

Protein ID

ICDB_Pro_0432

Protein Name

Potassium voltage-gated channel subfamily C member 1

Gene Name

Kcnc1

Organism

Rattus norvegicus (Rat)

Length

585 amino acids

AlphaFoldDB

AF-P25122-F1-model_v4.pdb

Function

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane; forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient . Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2; and possibly other family members as well . Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons

Sequence

MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDLCKESPVIAKYMPTEAVRVT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in brain (PubMed:1378392). Expressed in globus pallidal neurons of the basal ganglia (at protein level) (PubMed:10482766). Detected on Purkinje cells in the cerebellum molecular layer (at protein level) (PubMed:20857303).

DOI ID

10.1073/pnas.88.9.3932; 10.1002/j.1460-2075.1992.tb05312.x; 10.1152/jn.1999.82.3.1512; 10.1074/jbc.m310501200; 10.1007/s00418-010-0742-6; 10.1038/ncomms1871; 10.1016/j.bbagen.2013.10.025

RefSeq

NP_036988.1 [P25122-1]